RA CAPITAL MANAGEMENT, L.P. — 13F holdings

RA CAPITAL MANAGEMENT, L.P. reported 85 holdings worth $11.5B in its 13F filing for Q2 2026, filed August 14, 2026.

Largest positions

1. ASND Ascendis Pharma A/S — $2.74B (23.8%)
2. PBLS PARABILIS MEDICINES INC — $792M (6.9%)
3. RYTM RHYTHM PHARMACEUTICALS INC — $740M (6.4%)
4. PCVX Vaxcyte Inc — $667M (5.8%)
5. SION SIONNA THERAPEUTICS INC — $436M (3.8%)
6. TYRA TYRA BIOSCIENCES INC — $390M (3.4%)
7. EWTX EDGEWISE THERAPEUTICS INC — $341M (3.0%)
8. NAMS NEWAMSTERDAM PHARMA COMPANY — $324M (2.8%)
9. COAG HEMAB THERAPEUTICS HLDGS INC — $287M (2.5%)
10. SEPN SEPTERNA INC — $234M (2.0%)