SPRO Spero Therapeutics, Inc.: institutional ownership and insider trading
61 funds reported holding $52.7M of Spero Therapeutics, Inc. in their latest 13F filings; in Q2 2026 funds net bought $1.75M, with 20 new positions and 11 funds selling out; over the last 12 months insiders bought $0 and sold $552K on the open market.
Famous investors holding SPRO
- Renaissance Technologies (Renaissance Technologies): $2.09M, 0.0% of the portfolio
- Two Sigma (Two Sigma Investments): $846K, 0.0% of the portfolio
- Ken Griffin (Citadel Advisors): $145K, 0.0% of the portfolio
- Izzy Englander (Millennium Management): $42.6K, 0.0% of the portfolio
Largest institutional holders of SPRO
- GSK plc (GSK, GLAXF) — $20.3M
- PFIZER INC (PFE) — $5.34M
- VANGUARD GROUP INC — $4.85M
- VANGUARD CAPITAL MANAGEMENT LLC — $4.50M
- RENAISSANCE TECHNOLOGIES LLC — $2.09M
- Alphabet Inc. (GOOG, GOOGL) — $1.97M
- SUSQUEHANNA INTERNATIONAL GROUP, LLP — $1.78M
- BlackRock, Inc. (BLK) — $1.31M
- GEODE CAPITAL MANAGEMENT, LLC — $1.25M
- RAYMOND JAMES FINANCIAL INC (RJF, RJF-PB) — $1.15M
Recent SPRO insider trades
- May 4, 2026: Rajavelu Esther sold 25,240 shares ($63.4K)
- Feb 6, 2026: Keutzer Timothy sold 18,652 shares ($44.0K)
- Feb 6, 2026: Rajavelu Esther sold 87,917 shares ($207K)
- Feb 4, 2026: Keutzer Timothy sold 46,586 shares ($101K)
5%+ owners
- GSK PLC: 16.4% (Schedule 13D/A, filed Mar 28, 2025)