UPB Upstream Bio, Inc.: institutional ownership and insider trading
154 funds reported holding $414M of Upstream Bio, Inc. in their latest 13F filings; in Q2 2026 funds net bought $38.6M, with 35 new positions and 27 funds selling out; over the last 12 months insiders bought $0 and sold $105K on the open market.
Famous investors holding UPB
- Izzy Englander (Millennium Management): $7.91M, 0.0% of the portfolio
- D. E. Shaw (D. E. Shaw & Co.): $7.17M, 0.0% of the portfolio
- Renaissance Technologies (Renaissance Technologies): $909K, 0.0% of the portfolio
- Two Sigma (Two Sigma Investments): $293K, 0.0% of the portfolio
- Ken Griffin (Citadel Advisors): $104K, 0.0% of the portfolio
Largest institutional holders of UPB
- VANGUARD GROUP INC — $64.8M
- FMR LLC — $56.5M
- ORBIMED ADVISORS LLC — $39.4M
- NORGES BANK — $26.1M
- BlackRock, Inc. (BLK) — $26.0M
- Decheng Capital LLC — $18.9M
- Enavate Sciences GP, LLC — $17.0M
- VANGUARD CAPITAL MANAGEMENT LLC — $13.0M
- MILLENNIUM MANAGEMENT LLC — $7.91M
- D. E. Shaw & Co., Inc. — $7.17M
Recent UPB insider trades
- Sep 16, 2026: Ambrose Allison sold 485 shares ($2.66K)
- Sep 16, 2026: Gray Michael sold 853 shares ($4.68K)
- Sep 16, 2026: Houghton Adam sold 700 shares ($3.84K)
- Sep 16, 2026: Sutherland Everett Rand sold 2,095 shares ($11.5K)
5%+ owners
- Norges Bank: 7.7% (Schedule 13G/A, filed Aug 12, 2026)
- BlackRock, Inc.: 5.2% (Schedule 13G, filed Jul 30, 2026)
- Decheng Capital Global Life Sciences Fund IV, L.P.: 5.0% (Schedule 13G/A, filed May 15, 2026)