SEPN Septerna, Inc.: institutional ownership and insider trading
165 funds reported holding $1.69B of Septerna, Inc. in their latest 13F filings; in Q2 2026 funds net bought $82.6M, with 46 new positions and 15 funds selling out; over the last 12 months insiders bought $0 and sold $76.2M on the open market.
Famous investors holding SEPN
- Two Sigma (Two Sigma Investments): $7.40M, 0.0% of the portfolio
- Ken Griffin (Citadel Advisors): $2.95M, 0.0% of the portfolio
- Izzy Englander (Millennium Management): $1.69M, 0.0% of the portfolio
- D. E. Shaw (D. E. Shaw & Co.): $1.56M, 0.0% of the portfolio
- Renaissance Technologies (Renaissance Technologies): $1.39M, 0.0% of the portfolio
Largest institutional holders of SEPN
- RA CAPITAL MANAGEMENT, L.P. — $234M
- TRV GP V, LLC — $208M
- DRIEHAUS CAPITAL MANAGEMENT LLC — $148M
- TRV GP VI, LLC — $141M
- Samsara BioCapital, LLC — $105M
- GOLDMAN SACHS GROUP INC (GS, GSCE, GS-PA, GS-PC, GS-PD) — $103M
- BlackRock, Inc. (BLK) — $64.7M
- Siren, L.L.C. — $63.6M
- Avoro Capital Advisors LLC — $44.8M
- Jupiter Topco LLC — $43.7M
Recent SEPN insider trades
- Oct 15, 2026: Bhatt Elizabeth sold 4,000 shares ($150K)
- Sep 1, 2026: Long Daniel D. sold 3,333 shares ($126K)
- Aug 12, 2026: Third Rock Ventures V, L.P. sold 147,200 shares ($7.40M)
- Aug 12, 2026: RA Capital Healthcare Fund LP sold 1,493,000 shares ($63.5M)
5%+ owners
- RA Capital Management, L.P.: 11.8% (Schedule 13D/A, filed Aug 14, 2026)
- DRIEHAUS CAPITAL MANAGEMENT LLC: 9.8% (Schedule 13G/A, filed Aug 14, 2026)